In the present study, organic and inorganic nanosilica were evaluated against the terrestrial snail Eobania vermiculata including mortality percentage, some life-cycle aspects studied included, also their effects on change in some biochemical parameters in albino Wistar rats under laboratory conditions.LC50 values for organic and inorganic nanosilica treatments on the snail were 303.92µg/ml and 6.282×104 µg/g after five and three days of treatment respectively. Data showed significant results against E. vermiculata life- cycle aspects and new generation where treatments caused a reduction of copulation, oviposition and larva stage percentages reached {(50 and 25), (70.92 and 81.21) and (92.37 and 95.69) %} for organic and inorganic nanosilica respectively. On rats, there were highly significant changes in hematological parameters in rats, as there were a very high significant decreased in WBCs, 4.70 and 4.87 (103/µl) when treated with organic and inorganic nanosilica respectively, compared with 10.80 (103/µl) in the control, a very high significant decreased in MCV by 73.63 and 74.0 (fl) respectively, compared with 91.30 (fl) in the control, a significant increase in RBCs treated with organic nano silica by 7.30 (106/µl) and a very high significant increase reached 7.90 (106/µl) in treated with inorganic nanosilica compared with 6.77 (106/µl) in the control. Also, a very high significance was detected in PLT treated with organic nanosilica reached 832.0 (103/µl) and a highly significant increase in treated with inorganic nanosilica by 811.07 (103/µl) compared with 478.0 (103/µl) in the control.