Hexythiazox, diniconazole, difenoconazole,
spinetoram and methoxyfenozide pesticides were
applied on the fruits and leaves of grapes grown in
open field conditions. Their residues levels in fruits
and leaves of grapes were detected at different times
from initial times, one, three, seven and ten days af-
ter treatments. The rates of pesticide degradation,
half-life value (t1/2) and pre-harvest interval (PHI)
were also estimated. Pesticides were extracted and
cleaned-up from samples by the QuEChERS method
and then analyzed by HPLC-DAD. The estimated
t1/2 values were 2.4 and 4.4 days, 0.9 and 1.6 days,
5.4 and 2.9 days, 1.09 and 1.07 days and 3.3 and 8.5
days for hexythiazox, diniconazole, difenoconazole,
spinetoram and methoxyfenozide in fruits and leaves
of grapes, respectively. Pre-harvest interval (PHI)
values were 10 days and 15 days after application of
diniconazole , hexythiazox and spinetoram to fruits
and leaves of the grape .while pre-harvest interval
(PHI) values were 7 days and 10 days after applica-
tion of difenoconazole and methoxyfenozide to fruits
and leaves of the grape .The maximum residue limits
(MRL) were 0.5, 0.1, 3, 0.5 and 1 mg kg-1 for hex-
ythiazole, diniconazole, difenoconazole, spinetoram
and methoxyfenozide, respectively. The fast degra-
dation of hexythiazox, diniconazole, difenocona-
zole, and methoxyfenozide residues confirmed that
they could be used as safe pesticides to reduce the
health risks associated with the consumption of
treated grapes.