Hexythiazox, diniconazole, difenoconazole, spinetoram and methoxyfenozide pesticides were applied on the fruits and leaves of grapes grown in open field conditions. Their residues levels in fruits and leaves of grapes were detected at different times from initial times, one, three, seven and ten days af- ter treatments. The rates of pesticide degradation, half-life value (t1/2) and pre-harvest interval (PHI) were also estimated. Pesticides were extracted and cleaned-up from samples by the QuEChERS method and then analyzed by HPLC-DAD. The estimated t1/2 values were 2.4 and 4.4 days, 0.9 and 1.6 days, 5.4 and 2.9 days, 1.09 and 1.07 days and 3.3 and 8.5 days for hexythiazox, diniconazole, difenoconazole, spinetoram and methoxyfenozide in fruits and leaves of grapes, respectively. Pre-harvest interval (PHI) values were 10 days and 15 days after application of diniconazole , hexythiazox and spinetoram to fruits and leaves of the grape .while pre-harvest interval (PHI) values were 7 days and 10 days after applica- tion of difenoconazole and methoxyfenozide to fruits and leaves of the grape .The maximum residue limits (MRL) were 0.5, 0.1, 3, 0.5 and 1 mg kg-1 for hex- ythiazole, diniconazole, difenoconazole, spinetoram and methoxyfenozide, respectively. The fast degra- dation of hexythiazox, diniconazole, difenocona- zole, and methoxyfenozide residues confirmed that they could be used as safe pesticides to reduce the health risks associated with the consumption of treated grapes.