Background: Caregivers are an instrumental partner taking active participation in affecting the nature and direction of care process of hemophilic children. Parental competence and success in facing difficult circumstances may increase parental self-efficacy and serve as a protective factor against negative outcomes for children. Aim: The aim of this study was to evaluate the effect of an educational program on improving caregiver's competence level regarding care of children suffering from hemophilia. Design: A quasi-experimental design was utilized in the current study. Settings: The study was conducted at inpatient pediatric hematology units in Benha and Nile Health Insurance Hospitals. Sample: A purposive sample of 50 caregivers (mainly mothers) accompanying their children were selected from the above mentioned settings. Tools of data collection: Three tools were used: A structured interviewing questionnaire sheet, mothers' reported practices and parenting sense of competence scale. Results: There was a significant increase in mothers' competency level after one and three months of program implementation compared to pre-program. Conclusion: The educational program was an effective method in improving mothers' knowledge, their reported practices, and their competency level regarding care of children suffering from hemophilia. Recommendation: Establish a regularly training program for mothers who have children suffering from hemophilia and were newly diagnosed in order to improve their competency regarding care of their children.