Staff Members - Benha University
Dexmedetomidine versus Ketamine for the Prevention of Emergence Agitation in Pediatric: A Prospective, Randomized, and Controlled Clinical Trial
Open Journal of Anesthesiology • 2020
Publication Information
Authors
Elsayed Mohamed Abdelzaam*, Enas W. Mahdy
Keywords
Emergence Agitation, Ketamine, Dexmedetomidine
Journal
Open Journal of Anesthesiology
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: This study compares the effect of dexmedetomidine versus Ketamine
for the prevention of emergence agitation in children undergoing
general anaesthesia. Method: 75 Children are randomly allocated into three
groups. Group C: Were assigned to receive normal saline. Group K: Were assigned
to receive Ketamine 0.25 mg/kg. Group D: assigned to receive 0.25 ug
/kg of dexmedetomidine, before the end of surgery. Results: There was no
statistically significant difference in demographic data and intraoperative parameters
between the three groups. But as regards to time to discharge, there
was a significant difference between group C, group K and group D (group C
= 39.96 ± 2.84, group K = 37.28 ± 3.80, group D = 35.08 ± 3.36 and P value =
0.0002). FLACC scale was low after extubation, before leaving the operating
room and on arrival to PACU (small FLACC scale in group K, D than group
C). PAED scoreless in Group K and Group D than Group C (postoperative, at
10 minutes, 20 min, 30 min). Conclusion: Ketamine and dexmedetomidine
reduced the incidence and severity of emergence delirium effectively when
compared to normal saline, and the effects of dexmedetomidine being much
superior to Ketamine.
for the prevention of emergence agitation in children undergoing
general anaesthesia. Method: 75 Children are randomly allocated into three
groups. Group C: Were assigned to receive normal saline. Group K: Were assigned
to receive Ketamine 0.25 mg/kg. Group D: assigned to receive 0.25 ug
/kg of dexmedetomidine, before the end of surgery. Results: There was no
statistically significant difference in demographic data and intraoperative parameters
between the three groups. But as regards to time to discharge, there
was a significant difference between group C, group K and group D (group C
= 39.96 ± 2.84, group K = 37.28 ± 3.80, group D = 35.08 ± 3.36 and P value =
0.0002). FLACC scale was low after extubation, before leaving the operating
room and on arrival to PACU (small FLACC scale in group K, D than group
C). PAED scoreless in Group K and Group D than Group C (postoperative, at
10 minutes, 20 min, 30 min). Conclusion: Ketamine and dexmedetomidine
reduced the incidence and severity of emergence delirium effectively when
compared to normal saline, and the effects of dexmedetomidine being much
superior to Ketamine.