In the present study, newly hatched larvae laboratory strain of Pectinophora gossypiella, were treated with estimated LC50 values of Methomyl, Pyridalyl, Teflubenzuron and Verticillium lecanii 80% at concentration of 0.543, 698.11,61.859 and 0.2254 ppm respectively, to study their effects on duration of larval, pupal, total immature stages, longevity, fecundity and fertility of the resulting adults. The three tested compounds ( Methomyl, Teflubenzuron and V. lecanii) prolonged the larval duration by 18.81, 25.87 and 18.41 days/larvae, respectively, oppose to 15.10 days in control. Also, the aforementioned compounds increased the pupal period and the duration of total immature stages especially in case of the treatment with Teflubenzuron the period increased 2 times than control. In addition, the tested compounds caused considerable increase in female pre-ovipostion and post oviposition periods. The Methomyl and V. lecanii were significantly affected the oviposition period as it was shortened to 6.10 days and 10.6 days, respectively, while, in case of Pyridalyl and teflubenzuron prolonged it to 20.8 and 14.16 days, respectively, compared to 14.8 days for control. Also, the results obtained indicated reduction in the fecundity of the female and the percentage of hatchability.