Staff Members - Benha University
Pregnancy-induced low serum Ficolin levels may underlie the development of Pre-eclampsia and predict it
EFSS • 2020
Publication Information
Authors
Wagdy M Amer MD (1), Ali A Morsi MD (1), Hamasat A Alnoury MD (2)
Keywords
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Journal
EFSS
Publisher
Not Available
Volume
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Issue
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Abstract
Objectives: Estimation of serum ficolin-2 and -3 for normotensive pregnant women to find a
relation between ficolin levels and development of PE.
Patients & Methods: Primigravida attending the clinic prior to the 12th gestational week
underwent blood pressure (BP) measurements and gave blood sample for estimation of
fasting blood glucose (FBG) and ELISA estimation of serum ficolin. Enrolled women were
asked to attend 4-weekly for BP measurement; 59 PE women (Group PE), 59 normotensive
pregnant women (Group NT) and 59 non-pregnant women (Group NP) were enrolled.
Results: At time of PE diagnosis, all pregnant women had higher BP than their baseline
measures, with significantly higher measures in PE women. Serum ficolin-2 levels were
significantly lower in pregnant than NP women and in PE than NT women, while serum
ficolin-3 levels were significantly lower in PE than NT women. Development of PE was
positively associated with higher BMI, FBG and BP, while was negatively correlated with
ficolin levels. Regression analysis defined low serum ficolin levels as negative predictors for
PE development and serum ficolin-2 level
Objectives: Estimation of serum ficolin-2 and -3 for normotensive pregnant women to find a
relation between ficolin levels and development of PE.
Patients & Methods: Primigravida attending the clinic prior to the 12th gestational week
underwent blood pressure (BP) measurements and gave blood sample for estimation of
fasting blood glucose (FBG) and ELISA estimation of serum ficolin. Enrolled women were
asked to attend 4-weekly for BP measurement; 59 PE women (Group PE), 59 normotensive
pregnant women (Group NT) and 59 non-pregnant women (Group NP) were enrolled.
Results: At time of PE diagnosis, all pregnant women had higher BP than their baseline
measures, with significantly higher measures in PE women. Serum ficolin-2 levels were
significantly lower in pregnant than NP women and in PE than NT women, while serum
ficolin-3 levels were significantly lower in PE than NT women. Development of PE was
positively associated with higher BMI, FBG and BP, while was negatively correlated with
ficolin levels. Regression analysis defined low serum ficolin levels as negative predictors for
PE development and serum ficolin-2 level