Background: Atopic dermatitis is characterized by impaired skin barrier and altered cutaneous innate immunity. The
estimated prevalence among Egyptian children was 10–12%. Several studies suggest that it may be associated with
systemic comorbidities other than the spectrum of atopy, such as metabolic syndrome and other inflammatory conditions.
The aim of this study is to compare the profile of systemic conditions of diabetes, dyslipidemia, and multiple
inflammatory markers in children with and without diagnosed atopic dermatitis.
Methods: One hundred atopic dermatitis patients and 101 normal controls were collected from outpatient clinic
based on their clinical condition, both had measurement of body mass index, blood sugar, serum insulin, lipid profile,
C reactive protein, and gamma-glutamyl transferase.
Results: Children diagnosed with atopic dermatitis had significantly higher levels of body mass index (34.7 ± 5.7 vs
26.1 ± 4.9), fasting glucose (143.2 ± 30.3 vs 100.8 ± 16.0), serum insulin (11.3 ± 4.4 vs. 4.6 ± 3.0), serum triglycerides
(194.1 ± 38.1 vs 156.2 ± 31.6), total cholesterol (198.4 ± 27.7 vs 163.7 ± 27.7), alkaline phosphatase (229.4 ± 89.8 vs.
189.4 ± 46.8), and gamma-glutamyl transferase (54.7 ± 19.9 vs 34.3 ± 9.5), C-reactive protein level was approximately
four times higher (19.9 ± 13.2 vs 5.1 ± 3.4) and the immunoglobulin E level was approximately 10 times higher
(2050.3 ± 843.8 vs 252.7 ± 103.1) than in controls
Conclusion: We found a positive relationship of atopic dermatitis with both diabetes and hyperlipidemia among
children, and positive dose-response relationship of several non-traditional biomarkers of C-reactive protein, gammaglutamyl
transferase, and alkaline phosphatase with the presence and severity of atopic dermatitis.
Keywords: Atopic dermatitis, Diabetes, Dyslipidemia, C reactive protein, IgE, Glutamyl gamma transferase, Alkaline
phosphatase, Alkaline phosphatase