The effect of bolus dose of rernifentanil on the pressor responses to laryngoscopy
and tracheal intubation or extubation during rapid sequence
induction and recovery of anesthesia was assessed in a randomized,
double- blind, placebo- controlled study in two groups of 20 patients
each. No premedication was given. Anesthesia was induced with thiopental
5mg / kg. Followed by saline placebo or remifentartil 1.5 pg /kg and
suxamethonium. After the trachea get intubated, anesthesia maintained
with isoflurane and nitrous oxide in oxygen, at the end of surgery irthalational
anesthesia discontinued, the study drug readministered and residual
muscle relaxant was reversed. Mean arterial blood pressure, heart
rate and intra-ocular pressure were recorded immediately before induction,
before irttubatthn, at interval until 5 min after treachecd intubation,
before extubation and then at interval until 5 min after tracheal extubation.
There was a significant decrease in mean arterial pressure (MAP),
heart rate (1-IR) and irttraocular pressure in remifentand group (group R)
compared with saline placebo group (group S) from time of administration
of the study drugs to the end of the study at 5th min after extubation (Pc
0.001). we conculoded that remifentanil 1.5 pg/ kg administered during
induction and recovery, prevented the pressor response and increase in
lOP after irttubation or extubation.