Theme-Logo
  • Login
  • Home
  • Course
  • Publication
  • Theses
  • Reports
  • Published books
  • Workshops / Conferences
  • Supervised PhD
  • Supervised MSc
  • Supervised projects
  • Education
  • Language skills
  • Positions
  • Memberships and awards
  • Committees
  • Experience
  • Scientific activites
  • In links
  • Outgoinglinks
  • News
  • Gallery
publication name Indirect spectrophotometric determination of piroxicam and tenoxicam through oxidation with potassium permanganate
Authors A.S. amin, H.A. Dessouki, and K.M. Khalil
year 2010
keywords
journal
volume Not Available
issue Not Available
pages Not Available
publisher Not Available
Local/International International
Paper Link Not Available
Full paper download
Supplementary materials Not Available
Abstract

Three rapid, simple, accurate and selective validated spectrophtometric methods (A, B and C) for the determination of piroxicam (PX) and tenoxicam (TX) in bulk sample and in dosage forms are described. The methods are based on the oxidation of the studied drugs by a known excess of potassium permanganate in sulfuric acid medium and subsequent determination of unreacted oxidant by reacting it with Methylene Blue (Basic Blue 9) dye (method A), Acid Red 27 (Amaranth) dye (method B) and Acid Orange 7 (orange II) dye (method C), in the same medium at a suitable λmax = 660, 520 and 485 nm, respectively. The reacted oxidant was found to be corresponding to the drug content. Regression analysis of Beer-Lambert plots showed good correlations in the concentration ranges 1.0-8.0, 1.0-9.0 and 1.0-7.2 μg mL-1 using methods A, B and C, respectively, for PX and 0.3-7.0, 0.3-1.6 and 0.3-2.5 μg mL-1 using methods A, B and C, respectively, for TX. The stoichiometric ratios for the cited drugs to oxidant were studied. The optimum reaction conditions and other analytical parameters were evaluated. The proposed methods were applied successfully to determine the examined drugs either in pure form or pharmaceutical formulations with good accuracy and precision. The relative standard deviations were ≤ 0.33 with recoveries 98.9-101.7% for PX and ≤ 0.49 with recoveries 99.4-102.0% for TX.

Benha University © 2023 Designed and developed by portal team - Benha University