Objectives The current study aims to evaluate the prevalence of anosmia and the factors affecting it in coronavirus disease 2019 (COVID-19)-confirmed cases. Patients and methods A cross-sectional, multicenter study was conducted on 400 COVID-19-confirmed patients. The clinical data were collected from patients, either hospitalized in COVID-19 units of different isolation hospitals or home-quarantined, in Egypt. Data were collected through a predesigned survey-based 16 questionnaire, available in two forms, one in a written form and the other was online-designed by Google forms. Results The prevalence of anosmia was 68.8% in COVID-19-confirmed cases. About 41.1% of the patients had isolated anosmia. There were no significant differences between those with anosmia and those without as regards smoking and chronic rhinological status, P values were 0.118 and 0.132, respectively. Conclusion As a prevalent symptom of COVID-19 patients, anosmia will raise the suspicion index of health staff in developing countries with limited access to the COVID-19 test.