Staff Members - Benha University
Can trajectory nor-epinephrine infiltration reduce blood loss during percutaneous nephrolithotomy? A double-blinded randomized controlled trial
International journalof urology • 2022
Publication Information
Authors
Waleed El-Shaer, Mohamed Salah Haggag, Alaa Elshaer, Islam Shaboob, Wael Kandeel, Basheer Elmohamady, Dina Saad Abdelmotaleb, Sally Abdel-Lateef
Keywords
percutaneous nephrolithotomy, nor-epinephrine infiltration, bleeding
Journal
International journalof urology
Publisher
WILEY
Volume
29
Issue
12
Pages
1535-1542
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Purpose
To determine the efficacy and safety of trajectory infiltration with 1:150 000 Norepinephrine (NE) in reducing blood loss during percutaneous nephrolithotomy (PCNL).
Materials and methods
This is a prospective randomized double-blinded placebo-controlled trial. In all, 140 consecutive patients underwent PCNL for the management of large renal calculi. They were randomly assigned (1:1) to one of either study groups, the NE-PCNL group (70 patients whose PCNL-trajectory was infiltrated by NE) or the Placebo group (saline PCNL) (70 patients whose PCNL tracts were infiltrated by normal saline). Procedure-related blood loss (the primary outcome) was assessed and statistically analyzed. Also, all other procedure-related events and complications were recorded and compared.
Results
The median blood loss was 378 ml (IQR: 252–504) in the NE-PCNL group versus 592 ml (IQR: 378–756) in the S-PCNL group (p
To determine the efficacy and safety of trajectory infiltration with 1:150 000 Norepinephrine (NE) in reducing blood loss during percutaneous nephrolithotomy (PCNL).
Materials and methods
This is a prospective randomized double-blinded placebo-controlled trial. In all, 140 consecutive patients underwent PCNL for the management of large renal calculi. They were randomly assigned (1:1) to one of either study groups, the NE-PCNL group (70 patients whose PCNL-trajectory was infiltrated by NE) or the Placebo group (saline PCNL) (70 patients whose PCNL tracts were infiltrated by normal saline). Procedure-related blood loss (the primary outcome) was assessed and statistically analyzed. Also, all other procedure-related events and complications were recorded and compared.
Results
The median blood loss was 378 ml (IQR: 252–504) in the NE-PCNL group versus 592 ml (IQR: 378–756) in the S-PCNL group (p