Staff Members - Benha University
Case-controlled study on indirect hyperbilirubinemia in exclusively breast fed neonates and mutations of the bilirubin Uridine Diphosphate-Glucuronyl transferase gene 1A1
• 2017
Publication Information
Authors
Amal E. Mohammed a, Eman G. Behiry a, *, Akram E. El-Sadek b, Waleed E. Abdulghany b,
Dalia M. Mahmoud a, Abdelfattah A. Elkholy b
Keywords
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Journal
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Publisher
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Volume
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Issue
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
Objective: This study aims to investigate the association of neonatal indirect hyperbilirubinemia in
exclusively breast-fed infants with UGT1A1 (Uridine Diphosphate-Glucuronyl transferase 1A1)
polymorphism.
Methods: 50 neonates were classified into 2 groups: 1) 30 full term neonates with indirect hyperbilirubinemia
(gestational age (GA) 39.5 ± 1.2 weeks); 2) 20 apparently healthy full-term neonates.
Group 1 was further subdivided based on percentage of body weight lost: (A) less than 10%; (B) 10% or
more.
Results: There was a statistically significant decrease in weight at sample collection and significant increase
in indirect bilirubin level in patients group compared to control group, there was statistically
significant difference as regard to genotype frequency [G/G, G/A, A/A], and allele frequency (A,G) between
patients and control group. There was statistically significant increase in indirect bilirubin level in
G/A e A/A genotypes. By comparing subgroup (A) and subgroup (B), there was statistically significant
increase in total bilirubin level in subgroup (B). There was statistically high significant difference
regarding genotype frequency (G/G, G/A, A/A) and allele frequency (G, A) between subgroup A and B.
Multiple stepwise regression analysis was done using hyperbilirubinemia as a dependent factor and body
weight loss, genotype (G/A) and allele (A) as independent factors. Body weight loss, genotype (G/A) and
allele (A) was found to be significant independent predictors for hyperbilirubinemia.
Conclusion: The results of the present study revealed that UGT1A1 polymorphism can be used as a novel
predictor for neonatal hyperbilirubinemia in breast fed full term neonates.
© 2016 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. This is an open
access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
exclusively breast-fed infants with UGT1A1 (Uridine Diphosphate-Glucuronyl transferase 1A1)
polymorphism.
Methods: 50 neonates were classified into 2 groups: 1) 30 full term neonates with indirect hyperbilirubinemia
(gestational age (GA) 39.5 ± 1.2 weeks); 2) 20 apparently healthy full-term neonates.
Group 1 was further subdivided based on percentage of body weight lost: (A) less than 10%; (B) 10% or
more.
Results: There was a statistically significant decrease in weight at sample collection and significant increase
in indirect bilirubin level in patients group compared to control group, there was statistically
significant difference as regard to genotype frequency [G/G, G/A, A/A], and allele frequency (A,G) between
patients and control group. There was statistically significant increase in indirect bilirubin level in
G/A e A/A genotypes. By comparing subgroup (A) and subgroup (B), there was statistically significant
increase in total bilirubin level in subgroup (B). There was statistically high significant difference
regarding genotype frequency (G/G, G/A, A/A) and allele frequency (G, A) between subgroup A and B.
Multiple stepwise regression analysis was done using hyperbilirubinemia as a dependent factor and body
weight loss, genotype (G/A) and allele (A) as independent factors. Body weight loss, genotype (G/A) and
allele (A) was found to be significant independent predictors for hyperbilirubinemia.
Conclusion: The results of the present study revealed that UGT1A1 polymorphism can be used as a novel
predictor for neonatal hyperbilirubinemia in breast fed full term neonates.
© 2016 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. This is an open
access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).