Staff Members - Benha University
Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats. Histological and immunohistochemical study.
• 2017
Publication Information
Authors
Nahla El-Eraky El-Azab1* & Aisha E. Mansy2**& Abeer M. El-Mahalaway3***&Dina Sabry4
Keywords
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publication.type
International
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Abstract
Gastric ulcers are erosion of the gastric mucosa, which are the most prevalent
gastrointestinal disorders. Pomegranate fruits have many beneficial therapeutic effects.
Bone marrow mesenchymal stem cells (BMSCs) are a novel approach with promising
therapeutic potential for curing human diseases.
Objective: to evaluate the effect of pomegranate and BMSCs on experimentally
induced gastric ulcer in adult male rats.
Materials and methods: Fifty four adult male rats were divided into four groups. Group I
(Control). Group II (Gastric ulcer): Rats received 100% ethanol orally by gastric tube.
Group (III) subdivided into 3 subgroups: subgroup IIIa: gastric ulcer treated with
pomegranate &subgroup IIIb: gastric ulcer treated with BMSCs& subgroup IIIc: gastric
ulcer treated with pomegranate and BMSCs. Group IV(Untreated gastric ulcer). Fundus
of stomach specimens were prepared and examined using histological and
immunohistochemical techniques.
Results: Group II &IV showed various changes as deep erosion, marked damage of
most of the cells. The presence of the inflammatory cells in gastric mucosa were
supported by a significant increase of tumor necrosis factor α ( TNF-α) expression and
collagen fibers depositions(P
gastrointestinal disorders. Pomegranate fruits have many beneficial therapeutic effects.
Bone marrow mesenchymal stem cells (BMSCs) are a novel approach with promising
therapeutic potential for curing human diseases.
Objective: to evaluate the effect of pomegranate and BMSCs on experimentally
induced gastric ulcer in adult male rats.
Materials and methods: Fifty four adult male rats were divided into four groups. Group I
(Control). Group II (Gastric ulcer): Rats received 100% ethanol orally by gastric tube.
Group (III) subdivided into 3 subgroups: subgroup IIIa: gastric ulcer treated with
pomegranate &subgroup IIIb: gastric ulcer treated with BMSCs& subgroup IIIc: gastric
ulcer treated with pomegranate and BMSCs. Group IV(Untreated gastric ulcer). Fundus
of stomach specimens were prepared and examined using histological and
immunohistochemical techniques.
Results: Group II &IV showed various changes as deep erosion, marked damage of
most of the cells. The presence of the inflammatory cells in gastric mucosa were
supported by a significant increase of tumor necrosis factor α ( TNF-α) expression and
collagen fibers depositions(P