Little reviews are available about detailed clinical scoring as a tool for assessment of tendonitis in equine. The present investigation was designed to evaluate the clinical assessment scores of pain, heat, swelling and lameness of induced SDFT core lesion in donkeys treated with intralesional injection of PRP. The present study was carried out on two groups (group-I) 12 donkeys treated by intratendenious injection of freshly prepared platelet rich plasma (PRP) and (group-II) 7 donkeys control group and treated by intratendenious injection of normal saline (Placebo). The Clinical assessment scores were performed before induction, 5th, 15th, 30th, 45th, 60th and 90th days post induction of core lesion. The clinical assessment of the PRP treated group revealed significant (p ≤ 0.05) improvement of local heat and grade of lameness at 15th, 30th and 45th days post induction in addition to significant (p ≤ 0.05) improvement of the pain reaction, midmetacarpal circumference (MM-C) and medio-lateral width (MM-MLW) at 15th, 30th, 45th, 60th and 90th days post induction; and significant (p≤ 0.05) decreased of midmetacarpal dorso-palmar thickness (MM-DPTH) at 30th and 90th days post induction. The control group exhibited significant (p ≤ 0.05) decreased of the local heat at 45th and 60th; lameness at 45th and 90th days and pain reaction, MM-C, MM-MLW and MM-DPTH at 90th days post induction. Clinical assessment scores of pain, heat, swelling and lameness in the present investigations proved that these parameters could be valuable in the assessment of SDFT core lesions and monitoring the treatment of tendopathy in equines.