Staff Members - Benha University
Short-term Functional and Morphological Evaluation of Efficacy of Intravitreal Triamcinolone Acetonide in Diabetic Macular Edema
• 2017
Publication Information
Authors
Yousry Fekry Abdou, Tarek Mohammed Zaghloul, Salah El-Sayed Mady
Keywords
Diabetic macular edema, optical coherence tomography, mf-ERG
Journal
Not Available
Publisher
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Volume
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Issue
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Purpose: To evaluate short-term functional and morphological efficacy of intravitreal triamcinolone acetonide (IVTAM) injection in diabetic macular edema (DME) using Multi-focal Electroretinography (Mf-ERG) and Optical Coherence Tomography (OCT).
Methods: Mf-ERG & OCT testing were conducted on 25 eyes of 16 subjects with clinically significant macular edema (CSME) for analysis of macular function and macular morphology at base line, Best corrected visual acuity (BCVA) and intraocular pressure (IOP) also measured prior to intervention, then single intravitreal injection of 4 mg triamcinolone acetonide was done followed by evaluation of efficacy one month later using Mf-ERG, OCT, BCVA and IOP.
Results: Mean post-operative Mf-ERG P1 amplitude was 60.6 nv/deg2 compared to 42.5 nv/deg2 prior to injection, OCT central macular thickness (CMT) showed a mean reduction of 137 μm, BCVA showed a mean improvement of 2 lines as measured on Landolt's visual acuity chart, IOP showed a mean rise of 2.5 mmHg after intravitreal injection.
Conclusion: Intravitreal triamcinolone acetonide (IVTA) significantly reduced CMT 4 weeks after injection. Mf-ERG could be used as adjuvant method to evaluate macular function after IVTA injection. Short-term complications of IVTA do not appear to be prohibitive. Further studies is needed to assess the long-term efficacy, and the need for retreatment or using IVTA as adjuvant to other lines.
Methods: Mf-ERG & OCT testing were conducted on 25 eyes of 16 subjects with clinically significant macular edema (CSME) for analysis of macular function and macular morphology at base line, Best corrected visual acuity (BCVA) and intraocular pressure (IOP) also measured prior to intervention, then single intravitreal injection of 4 mg triamcinolone acetonide was done followed by evaluation of efficacy one month later using Mf-ERG, OCT, BCVA and IOP.
Results: Mean post-operative Mf-ERG P1 amplitude was 60.6 nv/deg2 compared to 42.5 nv/deg2 prior to injection, OCT central macular thickness (CMT) showed a mean reduction of 137 μm, BCVA showed a mean improvement of 2 lines as measured on Landolt's visual acuity chart, IOP showed a mean rise of 2.5 mmHg after intravitreal injection.
Conclusion: Intravitreal triamcinolone acetonide (IVTA) significantly reduced CMT 4 weeks after injection. Mf-ERG could be used as adjuvant method to evaluate macular function after IVTA injection. Short-term complications of IVTA do not appear to be prohibitive. Further studies is needed to assess the long-term efficacy, and the need for retreatment or using IVTA as adjuvant to other lines.