Staff Members - Benha University
Chronic zinc administration improves endothelial cell function and vascular reactivity in experimentally induced diabetes mellitus in rats.
• 2002
Publication Information
Authors
Mohamed Adel El- Sayed, Nasr N. Nazmy Ahmed S. Mohamed and Sherif W. Mansour.
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publication.type
International
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Abstract
An exaggerated oxidative stress has been postulated as the link between diabetes mellitus (D.M) and endolhelial dysfunction. This study aimed to investigate the possible therapeutic effect of chronic zinc administration (0.5% in drinking water) on re¬nal artery vascular reactivity and oxidative stress indices viz serum oxidized to reduced glutathione ratio (GSH/GSSG), trolox equivalent antioxidant capacity (TEAC) and lipohy-droperoxides (LPO) in experimentally-induced D.M by strep-tozotocin (STZ) (60 mg/kg i.p single dose) in rats. Using Dop-pler technique in this study indicated that chronic zinc administration significantly (p