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Effects of glimepiride (Amaryl) on biogenic amines content in different areas in the brain of adult diabetic male albino mice/rats.
J. Egypt. Soc. Pharmacol • 2001
Publication Information
Authors
M. H. M. Aly, M. E. Mansour, Ahmed S. Mohamed and
Keywords
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Journal
J. Egypt. Soc. Pharmacol
Publisher
Not Available
Volume
Not Available
Issue
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
This work was conducted to investigate the effect of glimepiride on
the brain chemical neurotransmitters norepinephrine (NE), serotonine (5-
HT), gamma-aminobutyric acid (GABA) and dopamine (DA) in different
brain areas namely cerebral cortex (C.C.), thalamus/ hypothalamus (TH),
midbrain (M.B.) and cerebellum (C.) in streptozotocin (STZ) induced
diabetes and to study the effect of Vit E separately and concomitantly with
glimepiride on the previous neurotransmitters. .-. ••
In diabetes induced experimentally in rats by streptozotocin (STZ) (50 mg/kg I.P) results of the present work showed significant elevation of NE level (P < 0.05) in CC, TH, and GABA in all tested brain areas and significant reduction of DA and 5HT levels (P0.05) of GABA, DA, NE and 5HT levels (P > 0.05) in all tested brain areas compared with diabetic non treated rats. Concomitant administrations of glimepiride (0.1 mg/kg orally) and Vit. E (0.1 mg/kg orally) showed significant reduction of GABA, significant elevation of 5HT levels (PO.05) in' all tested brain areas with significant reduction of NE level (PO.05) in CC, TH.
the brain chemical neurotransmitters norepinephrine (NE), serotonine (5-
HT), gamma-aminobutyric acid (GABA) and dopamine (DA) in different
brain areas namely cerebral cortex (C.C.), thalamus/ hypothalamus (TH),
midbrain (M.B.) and cerebellum (C.) in streptozotocin (STZ) induced
diabetes and to study the effect of Vit E separately and concomitantly with
glimepiride on the previous neurotransmitters. .-. ••
In diabetes induced experimentally in rats by streptozotocin (STZ) (50 mg/kg I.P) results of the present work showed significant elevation of NE level (P < 0.05) in CC, TH, and GABA in all tested brain areas and significant reduction of DA and 5HT levels (P0.05) of GABA, DA, NE and 5HT levels (P > 0.05) in all tested brain areas compared with diabetic non treated rats. Concomitant administrations of glimepiride (0.1 mg/kg orally) and Vit. E (0.1 mg/kg orally) showed significant reduction of GABA, significant elevation of 5HT levels (PO.05) in' all tested brain areas with significant reduction of NE level (PO.05) in CC, TH.