Staff Members - Benha University
Nitric oxide donors increase the pregnancy rate in patients with unexplained infertility undergoing clomiphene citrate stimulation and intrauterine insemination: a randomized controlled pilot study
Gynecological Endocrinology • 2016
Publication Information
Authors
Mohamed Abdel Razik, Seham El-Berry, Ahmed El-Nezamy, Ahmed Saad &
Ahmed Abdel Wahab
Keywords
Unexplained infertility, NO donors, IUI
Journal
Gynecological Endocrinology
Publisher
Taylor & Francis Group
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
This study evaluated the effects of nitric oxide donor’s treatment on the pregnancy rate and
uterine blood flow in patients with unexplained infertility undergoing clomiphene citrate
stimulation and intrauterine insemination. A total of 120 patients were randomly allocated to a
control group who received 100mg clomiphene citrate daily from day 5 to 9 of cycle plus
placebo vaginal tablets, and a study group received clomiphene citrate plus isosorbide
mononitrate 10mg vaginal tablets. Vaginal ultrasound was done before treatment and every
other day starting from day 12 of cycle to count mature follicles and ovulation was triggered by
IM injection of 10 000 IU hCG when one follicle measured 18mm followed by intrauterine
insemination after 36 h. The endometrial thickness, uterine arteries resistance and pulsation
indices, and endometrial vascular flow and vascular flow indices were measured before
treatment and at day of hCG injection. Results were analyzed after one cycle treatment using
the Mean ± SD, the Student t test and the Fisher Exact test. Significant result was considered at
p values50.05. The study group had significant higher pregnancy rate/cycle, higher
endometrial and lower uterine artery blood flow indices (p50.05).
uterine blood flow in patients with unexplained infertility undergoing clomiphene citrate
stimulation and intrauterine insemination. A total of 120 patients were randomly allocated to a
control group who received 100mg clomiphene citrate daily from day 5 to 9 of cycle plus
placebo vaginal tablets, and a study group received clomiphene citrate plus isosorbide
mononitrate 10mg vaginal tablets. Vaginal ultrasound was done before treatment and every
other day starting from day 12 of cycle to count mature follicles and ovulation was triggered by
IM injection of 10 000 IU hCG when one follicle measured 18mm followed by intrauterine
insemination after 36 h. The endometrial thickness, uterine arteries resistance and pulsation
indices, and endometrial vascular flow and vascular flow indices were measured before
treatment and at day of hCG injection. Results were analyzed after one cycle treatment using
the Mean ± SD, the Student t test and the Fisher Exact test. Significant result was considered at
p values50.05. The study group had significant higher pregnancy rate/cycle, higher
endometrial and lower uterine artery blood flow indices (p50.05).