Objectives This study aimed to compare the analgesic effect of ultrasound-guided transversus abdominis plane (TAP) block versus wound infi ltration in patients undergoing open inguinal hernia repair. Patients and methods A total of 60 male patients scheduled for open unilateral inguinal hernia repair under general anesthesia were randomly allocated into two equal groups: group W received wound infi ltration with 0.2 ml/kg of 0.25% levobupivacaine at the site of incision, and group T received ultrasoundguided TAP block with 0.5 ml/kg of 0.25% levobupivacaine. Time to fi rst analgesic request, total morphine requirement over 24 h, and visual analogue pain score at rest and during cough were assessed over the course of 24 h. Results Total morphine requirement during the fi rst 24 h was signifi cantly less in group T. A total of 21 patients in group W required supplemental morphine compared with 13 patients in group T. Time to fi rst analgesic request was signifi cantly longer in group T. Patients receiving TAP block had signifi cantly lower pain scores at rest for 12 h and on cough for 6 h after operation when compared with patients who received wound infi ltration. Conclusion TAP block provided more reliable and effective analgesia and less total 24-h postoperative morphine consumption compared with wound infi ltration with the local anesthetic. Keywords: local wound infi ltration, open inguinal hernia repair, transversus abdominis plane block