Background: Biomarkers in diagnostic and prognostic approaches in obstetric research efforts are gaining a global interest however the sensitivity and specificity of those biomarkers are considered an issue of research debate Aim: To investigate usefulness and reliability of implementing the usage of sFlt-1/PIGF ratio for predictability of the presence or absence of preeclampsia development. Methodology: A cohort and randomized research study was conducted on 50 pregnant cases, the course of pregnancy was observed extensively in randomly selected pregnant women. Personal and history data, personal habits, the course and pregnancy clinical outcome was recorded. Research study subjects were equally categorized in two groups as follows: the control group and the preeclampsia group. Serum levels of sFlt-1 and PIGF in obtained samples was determined retrospectively by usage of Elecsys assays on an electrochemiluminescence immunoassay platform and implemented to calculate the sFlt-1/PIGF ratio. Result: Comparative statistical analysis of soluble fms-like tyrosine kinase 1, placental growth factor and sFLT/PlGF ratio among term and preterm preeclampsia cases showed highly statistical significant difference between term and preterm research categories of preeclampsia cases as regards soluble fms-like tyrosine kinase 1 (pg/ml) 24-28 GA, 28-31 GA (p values