Staff Members - Benha University
Utility of 4-(isatin-3-ylideneamino) benzohydrazide in the synthesis of bioactive N-heterocyclic compounds.
Journal of Chemical & Pharmaceutical Research • 2014
Publication Information
Authors
MMH Arief, AA Aly, AA Khalil, HI Mohamed
Keywords
Not Available
Journal
Journal of Chemical & Pharmaceutical Research
Publisher
Not Available
Volume
6
Issue
2
Pages
327-335
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
4-(Isatin-3-ylideneamino) benzoic acid, was synthesized and converted into 4-
(isatin-3-ylideneamino) benzoyl chloride. Hydrazinolysis of the acid chloride afforded4-
(isatin-3-ylideneamino) benzohydrazide. The latter compound was used as a key precursor
for the synthesis of pyrazole, triazole, phthalazine, thiadiazole, and oxadiazole derivatives
via its reaction with different electrophilic reagents. Structures of all synthesized compounds
were elucidated from FT-IR, 1H-NMR, mass spectroscopy and elemental analyses.
(isatin-3-ylideneamino) benzoyl chloride. Hydrazinolysis of the acid chloride afforded4-
(isatin-3-ylideneamino) benzohydrazide. The latter compound was used as a key precursor
for the synthesis of pyrazole, triazole, phthalazine, thiadiazole, and oxadiazole derivatives
via its reaction with different electrophilic reagents. Structures of all synthesized compounds
were elucidated from FT-IR, 1H-NMR, mass spectroscopy and elemental analyses.