Staff Members - Benha University
Significance of BRAF and Nrf2 in evaluation of Serous Ovarian tumors
Egyptian Journal of Pathology • 2020
Publication Information
Authors
Amira E.Soliman1 (Msc) , Ghada A. Abd El-Fattah1 (MD),Taghreed A. Abd Elaziz1 (MD), Magda H. Nasreldin2 (MD) , Ahmed M. Khalil 3(MD MRCOG), Hala A. Agina1 (MD)
Keywords
Nrf2, BRAF, Immunohistochemistry, Serous ovarian tumors.
Journal
Egyptian Journal of Pathology
Publisher
Wolters Kluwer
Volume
40
Issue
1
Pages
28-36
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Abstract
Background: Ovarian carcinoma is the second leading cause of cancer-related deaths among females. Many treatment strategies have been developed; however, the prognosis is still poor. This study aims to evaluate the immunohistochemical expression of BRAF and Nrf2 in serous ovarian tumors and to correlate their expression with clinicopathological features of the cases.
Material and methods: This uncontrolled retrospective study was performed on 50 cases; benign (10), borderline (12) and malignant serous ovarian neoplasm (28). The malignant serous tumors included 9 low grade cases and 19 high grade cases. The immunohistochemical expression of Nrf2 and BRAF was correlated with clinicopathological features of prognostic importance.
Results: The mean of BRAF expression is increased in borderline but it is almost equal for low grade and high- grade carcinoma which was statistically significant (P value
Background: Ovarian carcinoma is the second leading cause of cancer-related deaths among females. Many treatment strategies have been developed; however, the prognosis is still poor. This study aims to evaluate the immunohistochemical expression of BRAF and Nrf2 in serous ovarian tumors and to correlate their expression with clinicopathological features of the cases.
Material and methods: This uncontrolled retrospective study was performed on 50 cases; benign (10), borderline (12) and malignant serous ovarian neoplasm (28). The malignant serous tumors included 9 low grade cases and 19 high grade cases. The immunohistochemical expression of Nrf2 and BRAF was correlated with clinicopathological features of prognostic importance.
Results: The mean of BRAF expression is increased in borderline but it is almost equal for low grade and high- grade carcinoma which was statistically significant (P value