Objectives: To compare the effectiveness of scoring systems in predicting stone-free rates (SFR) following retrograde intrarenal surgery (RIRS) for renal calculi up to 2 cm. Methods: We prospectively analyzed 172 patients who underwent RIRS for kidney stones attending to the urology department Benha university hospital. All Patients will be managed by FURS. All patients had a preoperative CT scan and postoperative imaging for comparison. We collected patient characteristics (sex, age, previous ipsilateral urinary tract surgery, preoperative ureteral stent placement), stone factors (total stone burden, stone number, stone density) and renal factors (anatomical abnormalities, stone location in a lower pole, number of calyceal involvement) and correlated the data against postoperative stone-free status (defined as residual fragment ≤ 4 mm). The Resorlu–Unsal Stone score (RUSS), and R.I.R.S. scoring system score were calculated for each patient who was enrolled in the study. Subsequently, stone scoring systems were compared as to their prediction of SFR and Sensitivity, specificity values and Area under the curve (AUC) using he ROC Curve (Receiver Operating Characteristic). Furthermore, multivariate analysis was done to determine whether the scoring systems associated with SFR and complications. Results: The median patient age was 45 (35–-56). The median RUSS and R.I.R.S scores were 1 (0–1) and 5(4–6) respectively. The overall SFR was 54% after 1 month postoperative. The R.I.R.S. scoring system was found to have a higher predictive value in predicting postoperative SFR than the other RUSS scoring systems (p