The world is still dependent on fossil fuels as a continuous and stable energy source, but rising concerns for depletion of these fuels and the steady increase in demand for clean “green” energy have led to the rapid growth of the renewable energy field. As one of the most available energy sources with high energy conversion efficiency, solar energy is the most prominent of these energies as it also has the least effect on the environment. Flat plate collectors are the most common solar collectors, while their efficiency is limited by their absorber’s effectiveness in energy absorption and the transfer of this energy to the working fluid. The efficiency of flat plate solar collectors can be increased by using nanofluids as the working fluid. Nanofluids are a relatively recent development which can greatly enhance the thermophysical properties of working fluids. In the present study, the effect of using Al2O3/Water nanofluid as the working fluid on the efficiency of a thermosyphon flat-plate solar collector was experimentally investigated. The results of this experiment show an increase in efficiency when using nanofluids as the working fluid compared to distilled water. It was found that Al2O3/water nanofluids are a viable enhancement for the efficiency of flat-plate solar collectors.