Background: Sepsis still has a high incidence even in developed countries. Acute kidney injury (AKI) frequently occurs in significant percentage of septic ICU critically ill patients with decimal prognosis. Early prediction of AKI and early interventions may improve outcome. The aim of this study is to examine if procalcitonin (PCT) can be used for early prediction AKI septic patients in ICU. Methods: 67 patients with sepsis were enrolled in this study. On admission, PCT was measured together with serum creatinine, urea, and other inflammatory markers. qSOFA was calculated at the emergency department. Patients were classified into two groups: AKI and non-AKI groups. Results: PCT had a significantly higher value among patients who developed AKI than non-AKI group (67.04±20.59 ng/ml vs. 36.84±18.36 ng/ml); p < 0.001. Also, PCT exhibited a good predictive role for AKI with the ROC area under the curve was. 0859 (p < 0.001). Conclusions: PCT may help in the early prediction of AKI among septic ICU patients.