Epoxide (2) was used to synthesize a number of new condensed and noncondensed heterocyclic systems. Thus, reaction of epoxide (2) with amines, hydrazines, active methylene compounds and Friedel-Craft s have been studied. On the other hand, epoxide (2) reacted with Grignard reagents and afforded (7a,b). However, epoxide (2) condensed with thiourea and glycine gave oxazolinethione and 2-morpholinone derivatives (8) and (9), respectively. Also, epoxide (2) reacted with acetic acid and gave (10). Action of different nitriles with epoxide (2) gave the hydroxy amide derivatives (11a-c), which underwent cyclization and afforeded 2-oxazoline derivatives (12a-c). ’