To compare between topical and intralesional mitomycin c in treatment of aurical keloids. Patients and methods: Prospective randomized study in which 40 patients had aurical keloids were included,they were divided into 2 groups, Group I included 32 Patients who underwent topical mitomycin c application after surgical removal of aurical keloids, while Group II included 8 cases who underwent intra-lesional injection of mitomycin c after surgical removal of aurical keloids. Results: The two groups showed no significant difference regarding patient or lesion criteria (p > 0.05). VSS decreased significantly from 10.63 and 11.0 down to 1.38 and 3.0 after treatment in topical and intra-lesional groups respectively (p < 0.001). Nevertheless, better improvement and satisfaction was detected in the topical group. Conclusion: Both topical and intra-lesional mitomycin c injection are effective methods in managing auricular keloids. Nevertheless, better VSS scores and patient satisfaction are reported with topical administration. Keyword: mitomycin,auricle,keloid