Ventilated patients have a high risk of developing ventilator associated Pneumonia through aspiration of contaminated secretions into the lower airway or by bacterial colonization of the airways. Lung compliance is considered an important clinical parameter in ventilated patients and may also be a clinical predictor of mortality in patients with significant respiratory failure. The aim of the current study was established to show the efficacy of manual hyperinflation (MHI) and suction on Lung compliance in ventilated patients in different body positions. Fifty ventilated patients their age ranged from 30-65 years old. The subjects were divided into three groups, group A formed of 20 patient received manual hyperinflation only in different position, group B formed of 20 patient received suction only in different position and group C formed of 10 patient received manual hyperinflation with and without suction in different position. The mean values of lung compliance (LC) in group A and group B were non –significant between different position. But in group C the mean values were significantly increased from (35.65±7.43) to (45.89±4.52) at supine and from (37.85±4.91) to (50.61±6.33) in head down position. It is suggested that applying manual hyperinflation plus suction produce significant improvement in static lung compliance with head down position rather than manual hyperinflation alone and there was non-significant improvement in static lung compliance after suction alone in different body position