Background and aims
Dexmedetomidine has been noticed to be safe and efficient in prolonging the
duration of peripheral nerve blocks. This study was designed to compare the length,
quality of postoperative analgesia, hemodynamic stability, and patient’s satisfaction
and number of patients requiring analgesia with the addition of dexmedetomidine to
bupivacaine versus plain bupivacaine in pectoral nerve block (pecs) for modified
radical mastectomy (MRM).
Patients and methods
These patients were randomly allocated using a computerized random number
generator into two groups: group I (control group) (30 patients) received 25 ml of
0.25% of plain bupivacaine that was used for modified pecs block. Group II (study
group) (30 patients) received 25 ml of 0.25% of plain bupivacaine plus
dexmedetomidine (Precedex) 1 μg/kg that were used for pecs block.
Results
The results showed a longer duration of analgesia in group II (21±3 h) in comparison
with group I (16±4 h). Statistical analysis showed a statistically highly significant
(P=0.006). Also, consumption of morphine was lower in group II (5±3 mg/24 h) in
comparison with group I (9±4 mg/24 h). Statistical analysis showed a statistically
significant (P=0.01).
Conclusion
Dexmedetomidine as an adjunct to bupivacaine helps increase the duration and
improves the quality of postoperative analgesia in pecs block without serious side
effects.