Staff Members - Benha University
Comparison of Histidine rich glycoprotein, a novel biomarker for sepsis, with traditional biomarkers in adult ICU patients.
• 2022
Publication Information
Authors
Mohammed A. Fouad1, Ahmed H. Abd Elrahman2and Marwa S. EL-Melouk
Keywords
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publication.type
Local
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Supplementary Materials
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Abstract
Sepsis is a major public healthcare problem. It remains a significant cause of morbidity and mortality
in intensive care units (ICU) all over the world. A lifesaving early specific diagnosis and treatment is a
challenge as no gold standard technique exists that can alone allow a rapid and reliable diagnosis of
sepsis. Histidine-rich glycoprotein (HRG) is a promising new biomarker of sepsis that can contribute
to enhance current sepsis diagnostic tools. The current study aimed to evaluate HRG as a diagnostic
biomarker for sepsis compared to the conventionally used biomarkers, procalcitonin (PCT) and Creactive protein (CRP). The study included 67 participants classified into 3 groups: Control (n=19),
systemic inflammatory response syndrome (SIRS) patients (n=24) and sepsis patients (n=24). Serum
HRG, CRP and PCT levels were measured by ELISA techniques. HRG level was significantly reduced in
sepsis patients compared with SIRS patients (P
in intensive care units (ICU) all over the world. A lifesaving early specific diagnosis and treatment is a
challenge as no gold standard technique exists that can alone allow a rapid and reliable diagnosis of
sepsis. Histidine-rich glycoprotein (HRG) is a promising new biomarker of sepsis that can contribute
to enhance current sepsis diagnostic tools. The current study aimed to evaluate HRG as a diagnostic
biomarker for sepsis compared to the conventionally used biomarkers, procalcitonin (PCT) and Creactive protein (CRP). The study included 67 participants classified into 3 groups: Control (n=19),
systemic inflammatory response syndrome (SIRS) patients (n=24) and sepsis patients (n=24). Serum
HRG, CRP and PCT levels were measured by ELISA techniques. HRG level was significantly reduced in
sepsis patients compared with SIRS patients (P