This study WllS dOlle on 44 pllticllts with P1l11l101lllr), tuberculosis. They were 33 (75%) lI1alcs, and II (25%) fClIllllcs. Thcir llgC rangcd frOIl1 17-53 yrllrs (mellll ± SI) = 37.64 ± 9,71 ycars). They werc classified nrconlill~ to chest x ra~' illto J groups. group A : 15 patiCllts wilh far :Hlvallccd lesion. group 8: 15 Illlticnts with 1Il0deratel~' alh-allced lesioll. alld group C: 14 patiellts with minimal lesion, The study also included 18 age and sex lIlatchcd hellithy individuals as a cOlltrol. All lire suhicrted to thorough history tal(ing. full clinical cxamination, complcte blood count (CBC), Erythrocyte sCllimclltation rate (ESR). chest x ray. tuherculin test, 111111 hllcteriologiclll cXllrnillatioll of sputUIIl for Mycohacterium tuherculosis including smear stained with Ziehl Neelscn (ZN) stllin :trHI culturc 011 Lowell.~teill ./enscn (1../) lI1edium. The circulating levcls of IL-18 and . ostcopolltin (OI'N) wcre also measurcd hy cllzyme lillked illlmullosorbellt assay (F-LlSA) method. Thc results slu)"l'd that the circulating le\'Cls of IL-18 and OPN were significantly higher ill patients wilh pulmonary tuherculosis thall in the control group (both P