Staff Members - Benha University
Procalcitonin, C-reactive Protein and White Blood Cells Count in Children With Community Acquired Pneumonia
• 2020
Publication Information
Authors
Mohamed M. Rashad a
, Yasser M. Ismail b
, Ahmad Ata Sobeih a
, Omar S. Abdel Aziz a
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: community-acquired pneumonia (CAP) is one of
the most common pediatric diseases. Early and accurate diagnosis
of CAP in children has a great value in avoiding
pneumonia complications and decreasing rates of pneumonia related
mortality. Aim of the work: this study aimed to investigate the role
of procalcitonin (PCT), C-reactive protein (CRP) and white blood
cells (WBCs) count in diagnosis of childhood CAP. Patients and
Methods: 90 infants and children aged from 2 months to 5 years
(60 months) were included in this study. They were divided into two
groups group I: 60 patients hospitalized for CAP and group II: 30,
age and sex matched, healthy controls attending the outpatient
clinics of the same hospitals for routine care. Chest x-ray was
performed to the patients group only, while WBCs
count, serum CRP, serum procalcitonin were applied to both
patients and controls. Results: WBCs count, neutrophil percentage, CRP
level, procalcitonin concentration were higher in the patients group than the controls with high
statistically significant difference (13.4±3.4 vs 8.3±1.7) (54.5±15.4 vs 37.2±6.7) (57.5±30.1 vs
5.7±5.6) (0.5±0.47 vs 0.07±0.04) respectively. Using the AUROC test WBCs count at cut-off
value >10.5 x103
cell/mm3
, CRP at cut-off value >20 mg/L, procalcitonin at cut-off value >0.17
ng/ml could predict presence of CAP in the patients with 83.3%, 85%, 86.7% sensitivity and
76.6%, 100%, 96.7% specificity respectively. Conclusion: evaluation of WBCs count, serum
CRP and serum procalcitonin concentration has an important role in diagnosis of CAP in infants
and children
the most common pediatric diseases. Early and accurate diagnosis
of CAP in children has a great value in avoiding
pneumonia complications and decreasing rates of pneumonia related
mortality. Aim of the work: this study aimed to investigate the role
of procalcitonin (PCT), C-reactive protein (CRP) and white blood
cells (WBCs) count in diagnosis of childhood CAP. Patients and
Methods: 90 infants and children aged from 2 months to 5 years
(60 months) were included in this study. They were divided into two
groups group I: 60 patients hospitalized for CAP and group II: 30,
age and sex matched, healthy controls attending the outpatient
clinics of the same hospitals for routine care. Chest x-ray was
performed to the patients group only, while WBCs
count, serum CRP, serum procalcitonin were applied to both
patients and controls. Results: WBCs count, neutrophil percentage, CRP
level, procalcitonin concentration were higher in the patients group than the controls with high
statistically significant difference (13.4±3.4 vs 8.3±1.7) (54.5±15.4 vs 37.2±6.7) (57.5±30.1 vs
5.7±5.6) (0.5±0.47 vs 0.07±0.04) respectively. Using the AUROC test WBCs count at cut-off
value >10.5 x103
cell/mm3
, CRP at cut-off value >20 mg/L, procalcitonin at cut-off value >0.17
ng/ml could predict presence of CAP in the patients with 83.3%, 85%, 86.7% sensitivity and
76.6%, 100%, 96.7% specificity respectively. Conclusion: evaluation of WBCs count, serum
CRP and serum procalcitonin concentration has an important role in diagnosis of CAP in infants
and children