Like many countries in arid and semi-arid regions, Egypt suffers the gradual decline in fresh water. Thus, alternative water resources should be a matter of concern to satisfy further increases in demand, particularly in agricultural sector. A case study of Tukh district, Al-Qalyubiyah Province, Egypt was carried out for assessing impacts of sewage effluent irrigation on soil properties and heavy metals contamination in soils. Sewage effluent contain higher values of pH, total dissolved and suspended solids, soluble ions, NH4-N, NO3-N and PO4-P compared to the corresponding values of Nile fresh water. Trace metals in sewage effluent were lower than the maximum recommended level, except Zn, Cd Pb and Ni. Sewage effluent improved soils physio-chemical properties by decreasing bulk density and increasing water holding capacity, organic carbon and available N, P, K, Fe and Mn, while deteriorated soil by increasing EC and pH. Levels of Pb and Zn in sewage irrigated soils were below the hazardous limit for agricultural purposes, while Cd and Ni surpassed the natural level, but did not exceed the maximum acceptable limit which means this soil can be used for agricultural under certain precautions.