Background: MRI describes the main features of the encountered different pathological lesions of the hand and fingers, as well as specifies the signal characteristics and location, which help to differentiate them. In general, a specific diagnosis may be achieved by taking into account the location of the lesion within the hand or wrist and its signal characteristics. Aim: The aim of the study is to evaluate the role of MRI in diagnosis of various hand and finger pathologies using different sequences. Methods: This is a prospective observational study of patients who suffers from hand or fingers swelling or trauma. The patients were investigated by MRI. Results: The study included 30 patients with hand or finger lesions who were evaluated by MRI and enrolled from Benha University hospitals. Conclusion: Magnetic resonance imaging is the preferable method of choice for evaluating various hand and finger lesions in traumatic and non-traumatic condition if conventional radiography isn’t enough.