Background: microscopic lumbar discectomy is a well established and a common procedurein spine surgery, and its results are generally good especially in adult population Objective: the aim of this study is to evaluate the safety and efficacy of microscopic lumbar discectomy in middle aged population and to assess the clinical early outcome. Study design: this is a non randomized non controlled prospective clinical trial case series on 20 patients, their age ranged from 20 to 45 years who had lumbar disc prolapsed and underwent microscopic lumbar discectomy in Benha University hospital from January 2017 to June 2018. Methods: eleven males and nine females of mean age (34.3±7.77 years) with radiculopathy due to lumbar disc prolapsed who failed non surgical treatment were included. Patients were clinically assessed using Visual Analogue Score VAS and Oswestry Disability Index ODI pre and postoperatively, also intraoperative and postoperative assessment were done. Results: hospital stay was short (1.2±0.41 day), surgery time was (1.7±0.4 hours), no blood transfusion was needed and no drains were put. Complications were minimal include one case of SCF leak (5%), on case of superficial infection (5%), and 2 cases had recurrence (10%). Significance improvement occurred in VAS and ODI; VAS improved from 7.55±0.83 to 1.8±1.15 (P