Staff Members - Benha University
BiomarkersofmyocardialinjuryinLupusnephritis
• 2020
Publication Information
Authors
MohamedE.T.ibrahim,ElmetwallyLotfyElshahawy,AshrafTalaat
Mahmoud,RehabSalahNasr,AhmedEMansour
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background
Cardiovasculardisease(CVD)isthemaincauseofdeathinsystemiclupus
erythematosus(SLE)andlupusnephritis(LN)patients.Thisstudyaimedto
evaluatetheprevalenceofmyocardialinjuryamongSLEpatientswithout
nephritisandLNpatients,determinewhetherserum high-sensitivitycardiac
troponinT(HS-cTnT)andcreatinephosphokinase-MB(CKMB)mighthelpto
identifyLN patientsatriskforCVD andidentifyLN asariskfactorfor
myocardialinjury.
Methods:
Thisstudywasconductedon50patients(30LNpatientsand20SLEpatients
withoutnephritis).TheSLEdiseaseactivityindex(SLEDAI)andSystemic
Lupus InternationalCollaborating Clinics Damage Index (SLICC/DI)were
assessed.Laboratoryinvestigations,cardiacenzymes(Hs-TnTandCKMB),
andtransthoracicechocardiographywereperformed.
Results:
OurresultsdemonstratedahigherprevalenceofCVDinLNpatients.28LN
(93.3%)versus10SLE(50%)patientshaddetectablehighsensitivitytroponin
(Hs-TnT)withamean(29.77±18.22ng/L)versus(7.2±6.21ng/L)respectively,
themeanvalueofcreatinephosphokinase-MB(CKMB)washigherinLNthan
SLEpatients(23.9±18.6ug/Lversus14.8±9.4ug/Lrespectively).Multilinear
Cardiovasculardisease(CVD)isthemaincauseofdeathinsystemiclupus
erythematosus(SLE)andlupusnephritis(LN)patients.Thisstudyaimedto
evaluatetheprevalenceofmyocardialinjuryamongSLEpatientswithout
nephritisandLNpatients,determinewhetherserum high-sensitivitycardiac
troponinT(HS-cTnT)andcreatinephosphokinase-MB(CKMB)mighthelpto
identifyLN patientsatriskforCVD andidentifyLN asariskfactorfor
myocardialinjury.
Methods:
Thisstudywasconductedon50patients(30LNpatientsand20SLEpatients
withoutnephritis).TheSLEdiseaseactivityindex(SLEDAI)andSystemic
Lupus InternationalCollaborating Clinics Damage Index (SLICC/DI)were
assessed.Laboratoryinvestigations,cardiacenzymes(Hs-TnTandCKMB),
andtransthoracicechocardiographywereperformed.
Results:
OurresultsdemonstratedahigherprevalenceofCVDinLNpatients.28LN
(93.3%)versus10SLE(50%)patientshaddetectablehighsensitivitytroponin
(Hs-TnT)withamean(29.77±18.22ng/L)versus(7.2±6.21ng/L)respectively,
themeanvalueofcreatinephosphokinase-MB(CKMB)washigherinLNthan
SLEpatients(23.9±18.6ug/Lversus14.8±9.4ug/Lrespectively).Multilinear