| publication name | BiomarkersofmyocardialinjuryinLupusnephritis |
|---|---|
| Authors | MohamedE.T.ibrahim,ElmetwallyLotfyElshahawy,AshrafTalaat Mahmoud,RehabSalahNasr,AhmedEMansour |
| year | 2020 |
| keywords | |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Background Cardiovasculardisease(CVD)isthemaincauseofdeathinsystemiclupus erythematosus(SLE)andlupusnephritis(LN)patients.Thisstudyaimedto evaluatetheprevalenceofmyocardialinjuryamongSLEpatientswithout nephritisandLNpatients,determinewhetherserum high-sensitivitycardiac troponinT(HS-cTnT)andcreatinephosphokinase-MB(CKMB)mighthelpto identifyLN patientsatriskforCVD andidentifyLN asariskfactorfor myocardialinjury. Methods: Thisstudywasconductedon50patients(30LNpatientsand20SLEpatients withoutnephritis).TheSLEdiseaseactivityindex(SLEDAI)andSystemic Lupus InternationalCollaborating Clinics Damage Index (SLICC/DI)were assessed.Laboratoryinvestigations,cardiacenzymes(Hs-TnTandCKMB), andtransthoracicechocardiographywereperformed. Results: OurresultsdemonstratedahigherprevalenceofCVDinLNpatients.28LN (93.3%)versus10SLE(50%)patientshaddetectablehighsensitivitytroponin (Hs-TnT)withamean(29.77±18.22ng/L)versus(7.2±6.21ng/L)respectively, themeanvalueofcreatinephosphokinase-MB(CKMB)washigherinLNthan SLEpatients(23.9±18.6ug/Lversus14.8±9.4ug/Lrespectively).Multilinear