The aim of this work was to investigate the effect of certain herbs on some bichemical parameters of experimentally induced diabetic rats. For this purpose one hundred and twenty male albino rats were used randomly and classified into: Control group: not received any thing. Diabetic group divided into: Subgroup (1): Control diabetic group injected with Streptozotcin not received any herbs. Subgroup (2): diabetic rats received Rosemary. Subgroup (3): diabetic rats received Cress. Subgroup (4): diabetic rats administrated Heliotropia. Subgroup (5): diabetic rats administrated Surangan. Subgroup (6): diabetic rats administrated a mixture of Rosemary +Cress+ Heliotropia +Surangan (M4).subgroup (7): diabetic rats received a mixture of Rosemary +Cress +Heliotropia+ surangan in addition to Sage + Artemisia + Termis + Fenugreek+ Dandelion (M9) All group were received the herbs for thirty days. Blood samples were collected from all animals groups at 10, 20 and 30 day from administration of herbs. The collected sera were subjected for determination of glucose, Lactate, insulin, glucagon, total cholesterol Triglycerides, HDL-Cholesterol and LDL-Cholesterol. The obtained results revealed that herbs especially M4, M9 and Rosemary ameliorate most of biochemical changes. Thus, Mixture of herbs M4, M9 and Rosemary are useful in diabetes.