Staff Members - Benha University
Fucoidan supplementation modulates hepato-renal oxidative stress and DNA damage induced by aflatoxin B1 intoxication in rats
Science of the Total Environment • 2021
Publication Information
Authors
Mohamed M. Abdel-Daima,b,⁎, Ahmed Abdeenc,d, Maroua Jaloulie, Afaf Abdelkaderd,f, Ameer Megahedg,h,
Abdullah Alkahtanea, Rafa Almeera, Norah M. Alhoshania, Norah S. Al-Johania, Saad Alkahtania,
Lotfi Aleyai
Keywords
Mycotoxins
AFB1
Fucoidan
Hepato-renal damage
Oxidative stress
PCNA
Journal
Science of the Total Environment
Publisher
Elsivier
Volume
768
Issue
10
Pages
144781
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Aflatoxins are a common food contaminant of global concern. Aflatoxin B1 (AFB1) intoxication is associated with
serious health hazards. Recently, fucoidan (FUC) has gained much attention from pharmaceutical industry due to
its promising therapeutic effects. The impacts of FUC on AFB1-induced liver and kidney injures have not been sufficiently
addressed. This research was conducted to evaluate the ameliorative effect of FUC in AFB1-induced hepatorenal
toxicity model in rats over 14 days. Five groups were assigned; control, FUC (200 mg/kg/day, orally),
AFB1 (50 μg/kg, i.p.), and AFB1 plus a low or high dose of FUC. AFB1 induced marked hepatorenal injury elucidated
by substantial alterations in biochemical tests and histological pictures. The oxidative distress instigated
by AFB1 enhanced production of malondialdehyde (MDA) and nitric oxide (NO) along with reduction in the reduced-
glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities.
DNA damage in the liver and kidney tissues has been demonstrated by overexpression of proliferating
cell nuclear antigen (PCNA). Unambiguously, FUC consumption alleviates the AFB1-induced mitochondrial dysfunction,
oxidative harm, and apoptosis. These ameliorated effects are proposed to be attributed to fucoidan's
antioxidant and anti-apoptotic activities. Our results recommend FUC supplementation to food because it exerts
both preventive and therapeutic effects against AFB1-induced toxicity.
serious health hazards. Recently, fucoidan (FUC) has gained much attention from pharmaceutical industry due to
its promising therapeutic effects. The impacts of FUC on AFB1-induced liver and kidney injures have not been sufficiently
addressed. This research was conducted to evaluate the ameliorative effect of FUC in AFB1-induced hepatorenal
toxicity model in rats over 14 days. Five groups were assigned; control, FUC (200 mg/kg/day, orally),
AFB1 (50 μg/kg, i.p.), and AFB1 plus a low or high dose of FUC. AFB1 induced marked hepatorenal injury elucidated
by substantial alterations in biochemical tests and histological pictures. The oxidative distress instigated
by AFB1 enhanced production of malondialdehyde (MDA) and nitric oxide (NO) along with reduction in the reduced-
glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities.
DNA damage in the liver and kidney tissues has been demonstrated by overexpression of proliferating
cell nuclear antigen (PCNA). Unambiguously, FUC consumption alleviates the AFB1-induced mitochondrial dysfunction,
oxidative harm, and apoptosis. These ameliorated effects are proposed to be attributed to fucoidan's
antioxidant and anti-apoptotic activities. Our results recommend FUC supplementation to food because it exerts
both preventive and therapeutic effects against AFB1-induced toxicity.