| publication name | DBU-Catalyzed transprotection of N-Fmoc-cysteine di- and tripeptides into S-Fm-cysteine di- and tripeptides. |
|---|---|
| Authors | Alan R. Katritzky, Nader E. Abo-Dya, Abdelmotaal Abdelmajeid, Srinivasa R. Tala, M. S. Amine and |
| year | 2010 |
| keywords | |
| journal | Org. Biomol. Chem |
| volume | 9 |
| issue | (2) |
| pages | 596–599 |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
The transprotection of N-Fmoc-cysteine containing di- and tripeptides possessing a free SH group to produce the corresponding S-Fm-cysteine di- and tripeptides bearing a free amino group is accomplished efficiently with DBU in dry THF. The N-Fmoc to S-Fm transformation mechanism is discussed. S-Fm-Cysteine di- and tripeptides readily form amide bonds on coupling with N-(Pg-a-aminoacyl)- benzotriazoles and N-(Pg-a-dipeptidoyl)benzotriazoles to give larger peptides.