The present study was designed to look at the hematological disorders in gentamicin nephrotoxicity model as the kidney is considered as one among the hemopoietic organs. In a previous study, novel and classical kidney injury biomarkers were utilized to evaluate the nephroprotective potential of Carica papaya leaf extract ( CPLE ) in the same model in albino rats. Gentamicin (100 mg/kg, subcutaneously, for 21 consecutive days) resulted in significant decreases in RBC count, Hb concentration, PCV value, with minimal alterations in erythrocytic indices. Leucogram showed leukocytosis, granulocytosis and thrombocytopenia. Erythropoietin levels were also drastically decreased by the end of the experimental course. Serum iron, unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), transferrin saturation% and serum transferrin concentration values were significantly decreased in contrast to ferritin that was increased. When concurrently administered with gentamicin, CPLE (150 and 300 mg/kg, orally via gastric tube, for 21 days) significantly protected against the drastic effects of the former on the blood profile with improving potentials on erythrogram, leukogram, thrombocytes, erythropoietin, iron and its indices, in a dose-dependent manner. These data may suggest CPLE as an appreciated blood homeostatic and nephroprotective agent from natural source that could be a good remedy in conditions associated with blood disorders.