Staff Members - Benha University
Sulphadimidine suppresses major histocompatibility complex (MHC) expression in broiler chicken.
British Journal Pharmacology Toxicology • 2012
Publication Information
Authors
22. A. El-Mahmoudy, M. E. Mahmoud, M. Draid, A. El-Magdoub and S. Awidat.
Keywords
B-cells, broiler chickens, bursa of fabricius, Major Histocompatibility Complex Class II
(MHC-II), sulphadimidine
Journal
British Journal Pharmacology Toxicology
Publisher
MAXWELL Scientific Publication Corp.
Volume
3
Issue
3
Pages
135-139.
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
The present study aimed at evaluation of the immuomodulatory effect of sulphadimidine by
investigating its ability to affect constitutive expression of MHC-II molecules on B-cells, which are
one determinant of antigen presentation and the vigor of immunity. Three groups of broiler chicken
were used, the first two groups received 100 mg/kg and 200 mg/kg sulfadimidine, respectively, in
drinking water; while the third group was left as control. Bursal samples were taken after 7 and 14
days of treatment and checked for MHC-II gene expression by RT-PCR technique. The obtained
results demonstrate that oral administration of sulphadimidine inhibited the expression of MHC-II
mRNA in bursal of Fabricius of broiler chicken in a dose and age dependent manner. This finding is
of clinical importance as many farmers routinely add sulpha drugs to drinking water as a prophylactic
measure against some infections; yet the data presented in this study doesn't recommend this
managing behavior.
investigating its ability to affect constitutive expression of MHC-II molecules on B-cells, which are
one determinant of antigen presentation and the vigor of immunity. Three groups of broiler chicken
were used, the first two groups received 100 mg/kg and 200 mg/kg sulfadimidine, respectively, in
drinking water; while the third group was left as control. Bursal samples were taken after 7 and 14
days of treatment and checked for MHC-II gene expression by RT-PCR technique. The obtained
results demonstrate that oral administration of sulphadimidine inhibited the expression of MHC-II
mRNA in bursal of Fabricius of broiler chicken in a dose and age dependent manner. This finding is
of clinical importance as many farmers routinely add sulpha drugs to drinking water as a prophylactic
measure against some infections; yet the data presented in this study doesn't recommend this
managing behavior.