This study investigated the effectiveness of using An ESP program based on Cognitive Academic Language Learning Approach (CALLA) in developing academic reading and technical writing among Microbiology and Biochemistry first year students at the Faculty of Science, Obourr Campus, Benha University. The study followed a pre-post experimental one group design. The participants were 37 students. The researcher used a needs analysis questionnaire to determine their academic needs. Moreover, the results of the questionnaire indicted their needs to academic reading and technical writing skills. The researcher designed academic reading test and technical writing test. Students were pre-tested, to identify their entry level of academic reading and technical writing skills .Then; they were trained through the ESP CALLA- based program on how to develop their academic reading and technical writing skills. The post-test was applied to the participants to assess the progress in their level of performance in academic reading and technical writing skills. Findings of the study revealed that there was statistically a significant difference at 0.01 in the pre- and post-assessment of academic reading and technical writing skills in favour of the post-assessment. Therefore, the ESP program that based on CALLA was effective in enhancing academic reading and technical writing skills.