Müller-Weiss disease (MWD) is a painful foot condition characterized by deformity, sclerosis, and fragmentation of the navicular. The diseased navicular is characteristically comma shaped with varying degrees of arthritis present at the talonavicular and naviculocuneiform joints.17,19,27 Other names for MWD include Brailsford disease,37 adult tarsal scaphoiditis,26 spontaneous adult navicular osteonecrosis,34 and listhesis navicularis.23 There is substantial controversy regarding the etiology, pathophysiology, and natural history of MWD, as well as optimal methods of treatment. This article reviews the historical and current literature regarding MWD, including the latest surgical interventions that have been reported.