uremic induced phrenic neuropathy may account for diaphragmatic involvement in patients with end-stage renal disease on dialysis.Objective: Toassess the occurrence of phrenic neuropathy and its relationship with hyperkalaemia and frequency of dialysis in patients with chronic renal failure on dialysis.Subjects and Methods:The study included 27 patients with chronic renal failure on dialysis and 27 controls. All the patients and controls were subjected to history taking, neurological examination, laboratory tests, neurophysiological study of phrenic and peripheral nerves and scales to assess the severity of symptoms and disability caused by peripheral neuropathy. Results:Of the 27 patients, (70.4%) had Phrenic Motor Neuropathy, (33.4%) had Median Motor Neuropathy, (48.2%) had Median sensory Neuropathy, (40.8%) had Peroneal Motor Neuropathy and (66.7%) had Peroneal Sensory Neuropathy with highly statistically significant difference of Neuropathy detected between patients and control. Infrequent dialysis was cause bilateral mixed (44.4%) and axonal (33.3%) phrenic motor neuropathy. Bilateral mixed Phrenic Motor Neuropathy was more frequent in hyperkalaemia group (31.2%). Conclusion:Phrenic neuropathy is a frequent complication of chronic renal failure patients on dialysis especially those with hyperkalaemia and infrequent dialysis.