Staff Members - Benha University
Evaluation of Serum Autotaxin as a Novel Noninvasive Marker for Assessment of Hepatic Fibrosis in Chronic Hepatitis C Patients
• 2016
Publication Information
Authors
Mahmoud A. Al-Azoony1, Jehan H.Sabry2, Hisham A. Issa3, Maha Z. Omar4,
Abdelmoneam Ahmed5, Doaa M. Abd Almoneim
Keywords
Hepatitis C, autotaxin, hepatic fibrosis.
Journal
Not Available
Publisher
Not Available
Volume
4
Issue
11
Pages
14128-14139
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Egypt has a high prevalence of HCV infection which causes hepatic fibrosis. Assessment of the degree of
hepatic fibrosis is essential for decision of antiviral therapy. Untill now, liver biopsy is the gold standard for
assessment of hepatic fibrosis but it is an invasive procedure. The aim of this study was to assess the utility of
serum autotaxin level as a marker of liver fibrosis in chronic hepatitis C patients in comparison with liver
biopsy.Sixty HCV patients with hepatic fibrosis confirmed with liver biopsy and20 healthy subjects were
inrolled in the current study.Lab assessment included CBC, fasting serum glucose, liver and kidney function
tests, serum AFP, hepatitis markers (HCVAb, HBsAg), PCR for HCV RNA and serum autotaxin (using
sandwich ELISA).Results revealed that serum ATX levels were significantly increased in HCV group versus
control group and were positively correlated with the stage of fibrosis. Serum autotaxin level at cutoff value
(
hepatic fibrosis is essential for decision of antiviral therapy. Untill now, liver biopsy is the gold standard for
assessment of hepatic fibrosis but it is an invasive procedure. The aim of this study was to assess the utility of
serum autotaxin level as a marker of liver fibrosis in chronic hepatitis C patients in comparison with liver
biopsy.Sixty HCV patients with hepatic fibrosis confirmed with liver biopsy and20 healthy subjects were
inrolled in the current study.Lab assessment included CBC, fasting serum glucose, liver and kidney function
tests, serum AFP, hepatitis markers (HCVAb, HBsAg), PCR for HCV RNA and serum autotaxin (using
sandwich ELISA).Results revealed that serum ATX levels were significantly increased in HCV group versus
control group and were positively correlated with the stage of fibrosis. Serum autotaxin level at cutoff value
(