Objectives: To evaluate the role of the topical corticosteroid, mometasone furoate, nasal spray in the treatment of
post COVID-19 anosmia.
Methods: A prospective, randomized, controlled trial was conducted among patients with post COVID-19
anosmia. One hundred patients were randomly assigned to two groups; group I included 50 patients received
mometasone furoate nasal spray in an appropriate dose of 2 puff (100 μg) once daily in each nostril for 3 weeks
with olfactory training, group II included 50 patients were advised to keep on olfactory training only. The
assessment of smell was done using (Visual Analog Scale from 0 to 10). All patients were initially evaluated after
their recovery from COVID-19 and followed up for 3 weeks. The smell scores were recorded weekly and the
duration of smell loss was recorded from the onset of anosmia till the full recovery.
Results: In both groups, the smell scores significantly improved by the end of the third week (P < 0.001). By
comparing smell scores between both groups after 1 week, 2 weeks, and 3 weeks of treatment, there were no
statistically significant differences between both groups. In group I, (62%) of patients completely recovered their
sense of smell after 3 weeks of treatment, compared to (52%) of patients in group II (P = 0.31).
Conclusion: The results suggested that using mometasone furoate nasal spray as a topical corticosteroid in the
treatment of post COVID-19 anosmia offers no superiority benefits over the olfactory training, regarding smell
scores, duration of anosmia, and recovery rates.
Trial registration: ClinicalTrials.gov ID: NCT04484493