Warts are benign epithelial proliferations of the skin and mucous membranes caused by human
papilloma viruses (HPVs). Plane warts are mainly caused by HPV-3 and HPV-10. There is no
absolute effective single treatment, and multiple treatment modalities may be combined. One
must take into consideration the probability of spontaneous regression, and so the therapeutic
approach should not be too aggressive. We report a case of 11 years immunocompetent child
presenting with recalcitrant multiple plane warts who was successfully treated with intralesional
2% zinc sulfate solution injection in one lesion after a failure of many other treatment modalities.
Our case may represent a starting point for further studies to evaluate the best dose used
for management and to avoid any side effects. Intralesional zinc sulfate injection could be a
promising treatment option for plane warts.