Cefoperazone was given intramuscularly to female albino rats at a dose of 180 and 360 mg/ Kg body weight over a period of 6‐15 days of pregnancy during which organogenesis of feti occur .The dams were killed on day‐ twenty of gestation and their feti were subjected to morphological , visceral and skeletal examinations. The drug was significantly decreased the number of viable feti and significantly increased the number of resorbed feti. No dead feti and induced retardation in growth of viable feti, some visceral and skeletal defects in these feti were seen. These effects were dose dependant .Histopathological changes of female organs were seen in liver, kidney, skeletal, muscle, placenta, heart, spleen and brain. Conclusively, cefoperazone caused some fetal defects and abnormalities as well as some histopathological changes in female organs. Accordingly, it is advisable to avoid uses of this drug during pregnancy.