Fifteen, 4-8 months old goats were used to study the effect of diclofenac potassium and dexamethasone on some hematobiochemical parameters, as well as immunity. Animals were divided into 3 groups (5 buck each) 1st group was left without treatment as control while 2nd and 3rd groups were treated by diclofenac potassium (1.1 mg/kg b.wt.) and dexamethasone (0.20 mg/kg b. wt.) respectively as therapeutic dose for 5 successive days. Two blood samples were collected from on 1st, 7th and 14th days after the last injection of both drugs for leukogram and biochemical analysis. The results revealed that, diclofenac potassium and dexamethasone induced significant increase in total leucocytic count, neutrophil, monocyte, basophil, esionophil, ALT, AST, urea and creatinine, calcium, potassium and inorganic phosphorus, beside significant decrease in lymphocyte, total protein, albumin, globulin ALP and sodium also significant decrease in in RBCs, Hb, PCV, IgA, IgG, IgM, on the 1st. and 7th after the last injection was recorded. It could be concluded that both diclofenac potassium and dexamethasone induced several hematobiochemical and immunological changes as well as the adverse effects of diclofenac potassium were completely reversible within 14 days while they were incompletely reversible within 14 days with dexamethasone.