CKD is a common disorder and its prevalence is increasing worldwide. Early diagnosis could permit early intervention to reduce the risks of cardiovascular events, kidney failure, and death which associated with chronic kidney disease.The progression of established CKD is variable and depends on several risk factors or markers. Non modifiable factors include genetics, race, age, and sex. the modifiable factors include systemic hypertension, Proteinuria, Metabolic factors ( The Diabetes Control, hyperlipidaemia, hyperuricaemia, obesity).Primary prevention will rely on controlling the global epidemic of obesity and associated type 2 diabetes as well as hypertension, Lifestyle modifications. Secondary prevention of progression In patients with established CKD, there is a wide range of interventions that offer the possibility of slowing progression. [El Metwally Lotfy, Mohammed El sayed, Sameh Bhagat, Ashraf Talaat and Shimaa Salah Prevention of chronic kidney disease (CKD) & novel treatment Nat Sci2015;13(x):-]. (ISSN: 1545-0740). http://www.sciencepub.net/nature.